منابع مشابه
Genetics of inflammatory bowel disease.
1. The aetiology of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis, is uncertain. Studies of specific environmental factors and immune dysfunction have provided little insight into disease pathogenesis. 2. Concordance rates in twin pairs and siblings provide strong evidence that genetic factors are important in disease pathogenesis. In Oxford, information was ob...
متن کاملNeonatal Presentation of Unremitting Inflammatory Bowel Disease
Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...
متن کاملGenetics and phenotypes in inflammatory bowel disease
98 www.thelancet.com Vol 387 January 9, 2016 risk of stroke, the most likely explanation for which is embolisation of thrombus to the systemic circulation during removal of the thrombectomy catheter. Is selective use of thrombectomy in selected patients reasonable? None of the subgroup analyses in TOTAL, including patient age, presence of diabetes, coronary fl ow grade, smoking status, location...
متن کاملInflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent research has suggested that genetic factors, environment, microbiota, and immune response are involved in the pathogenesis. Epidemiological evidence for a genetic contribution is defined: 15% of patients with Crohn...
متن کاملGenetics of Inflammatory Bowel Diseases.
In this review, we provide an update on genome-wide association studies (GWAS) in inflammatory bowel disease (IBD). In addition, we summarize progress in defining the functional consequences of associated alleles for coding and noncoding genetic variation. In the small minority of loci where major association signals correspond to nonsynonymous variation, we summarize studies defining their fun...
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ژورنال
عنوان ژورنال: Clinical Science
سال: 1998
ISSN: 0143-5221,1470-8736
DOI: 10.1042/cs0940473